International Society for Phytocosmetic Sciences International Journal of Phytocosmetics and Natural Ingredients 2374-0639 8 1 2021 01 01 Separation of antioxidants from apple (Malus domestica) red peels and formulation of a daily face cream 2 2 10.15171/ijpni.2021.02 EN Alexandra Mamagkaki Ioannis Papasotiriou Journal Article 10.15171/ijpni.2021.02 2020 12 01 2021 01 30 Background: Apples (Malus domestica) are a part of most daily diet. Their positive impact on health and overall wellness is recognized and widely accepted. Nowadays, the demanding industry of cosmetology has raised awareness over the potent dangers of the ingredients and consumers tend to reach out for products more nature based and gentle. In this study, the development of different extraction methods for the isolation of antioxidants from apples’ peels was tried and the evaluation of their efficacy. In addition to this, it was aimed to formulate a simple daily face cream using this extract and prove its action. Materials and Methods: This product was tested for its allergens, its stability and its preservative efficacy with the target to conclude to not only an effective daily cream but to a safe product ready to be used. Moreover, the antioxidant activity of the extract was determined as a single extract as well as after its encapsulation in the face cream. Results: The most common extraction methods were followed and showed that at 200μg/mL concentration the scavenging activity of some extracts is more than 80%. The formulation of those in a product, appeared to have successful results, since the antioxidant value of the peels remained in the product which proved to have a satisfying preservation system, no unforeseen allergens and great stability behavior under different conditions of storage. Conclusion: This study suggests the extraction of apples’ peels and the separation of antioxidant compounds. The findings prove that these kind of ingredients can be used in a product successfully and lead to the daily use by consumers.