Submitted: 05 May 2019
Revision: 17 Nov 2019
Accepted: 29 Nov 2019
ePublished: 26 Dec 2019
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Int J Phytocos Nat Ingred. 2019;6(1): 14.
doi: 10.15171/ijpni.2019.14
  Abstract View: 2182
  PDF Download: 1673

Review Article

Development of effervescent medical powder containing Maytenus ilicifolia extract Mart. ex Reissek for treatment of gastric disorders

Niraldo Paulino 1,2*, Gisele Fernanda Vieira 1, Minoru Ikegawa da Silva Braga 1, Luana Beatriz de Lima Carvalho 1, Isaias Pompeu Bernardo 1, Vanessa Franquini Nogueira 1

1 Faculdade de Guarulhos, Grupo Universidade Brasil, Av. Guarulhos, 1844 - Vila Augusta, Guarulhos, SP, 07025-000
2 Medical Lex Gestão de Informações e Cursos Ltda, Av. Desemb. Vitor Lima, 260, sala 908, Trindade, Florianópolis, SC, 88040-400
*Correspondence to Niraldo Paulino Email:


Brazil is the country with the biggest biodiversity on the planet, but it does not avail itself enough of this potential to produce herbal medicines. Maytenus ilicifolia Mart. Ex Reissek is popularly known as “Espinheira-Santa” and in Brazil is widely used in popular medicine to treat a number of diseases such as gastritis and dyspepsia, and also displays laxative, diuretic, analgesic, antiseptic and healing properties and antineoplastic and antimicrobial activities. Among the reasons that hinder a better exploration of such biodiversity, the absence of an innovative culture draws a lot of attention, besides the inherent difficulties in the characteristics of the research and the development of this product modality. The aim of this study was developing an effervescent powder containing medicinal extract of M. ilicifolia. The methodologies to determine quality of the plant and extract including the organoleptic characteristics, the moisture content and volatiles, total ashes, extractive content, pH, and the bulk density. In our experiments, we demonstrated that the plant has been identified and has displayed the appropriate organoleptic characteristics to the preparation of the extract; we also demonstrated that the extract has been incorporated into a formulation that maintained its organoleptic characteristics, pH and content, as well as the formation of stable gases. With these experiments, we demonstrate for the first time that the developed formulation can serve as a prototype for the development of pharmaceutics effervescent product containing standardized extract of M. ilicifolia.
Keywords: Effervescent salt, Maytenus ilicifolia, gastritis
Please cite this paper as: Paulino N, Vieira GF, da Silva Braga MI, de Lima Carvalho LB, Bernardo IP, Nogueira VF. Development of effervescent medical powder containing Maytenus ilicifolia extract Mart. ex Reissek for treatment of gastric disorders. Int J Phytocos Nat Ingred. 2019;6:14. doi:10.15171/ijpni.2019.14.
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