Submitted: 13 Nov 2015
Accepted: 24 Nov 2015
ePublished: 19 Dec 2015
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Int J Phytocos Nat Ingred. 2015;2(1): 15.
doi: 10.15171/ijpni.2015.15
  Abstract View: 3578
  PDF Download: 2347

Original Research

Antioxidant, Antibacterial and Hypoglycemic Activity of Extracts from Thymelaea microphylla Coss. et Dur.

Saliha Dahamna 1*, Khadidja Dehimi 1, Mounira Merghem 1, Meriem Djarmouni 2, Dalila Bouamra 1, Daoud Harzallah 3, Seddik Khennouf 1

1 Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Natural and Life Sciences, University Setif1, 19000, Algeria
2 Laboratory of Applied Biochemistry, Department of Biochemistry, Faculty of Natural and Life Sciences, University Sétif1, 19000, Algeria
3 Laboratory of Applied Microbiology, Department of Microbiology, Faculty of Natural and Life Sciences, University Sétif1, 19000, Algeria
Saliha Dahamna dahamna_s@yahoo.fr

Abstract

The objective of this study was to evaluate different biological activities of aqueous and ethanolic extracts from Thymelaea microphylla. Antioxidant capacity was determined using two methods: 2,2-diphenyl- 1-picrylhydrazyl (DPPH) radical scavenging assay, and the inhibition of lipid peroxidation using the β-carotene/linoleate model system. Disc diffusion method was used to evaluate the antibacterial activity on four different strains. Hypoglycemic effect of aqueous extract was tested in rats. Aqueous and ethanolic extracts showed a good antioxidant activity with IC50 of 0.1 and 0.2 mg/ml in DPPH test, and RRA% of 46.40% and 77.86% in β-carotene/linoleate assay respectively. Both extracts had no antibacterial effect on studied strains. A single administration of aqueous extract at a dose of 250 mg/kg bodyweight caused a very significant decrease in blood glucose level in rat.
Keywords: Antibacterial activity, β-carotene/linoleate, DPPH, Hypoglycemic activity, Thymelaea microphylla
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